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Basis for Duodenal Cancer Diagnosis
1.Tumor mucin testing Assessment of mucin expression profiles can help clarify the tumor’s tissue of origin (including differentiation from periampullary cancers) and support individualized treatment planning.
2.Histopathological examination The diagnostic gold standard. Histology most commonly shows adenocarcinoma, with a minority of cases being mucinous adenocarcinoma or undifferentiated carcinoma.
3.Fecal occult blood testing A basic noninvasive screening method; results may be positive when tumor ulceration causes gastrointestinal bleeding.
4.Air–barium double-contrast study A preferred examination that can demonstrate mucosal irregularity, bowel wall rigidity, or filling defects.
5.Duodenal fiberoptic endoscopy Allows direct visualization of lesions and biopsy sampling; however, lesions in the third and fourth portions of the duodenum may be missed.
6.Ultrasonography, endoscopic ultrasonography, and CT Used to assess depth of bowel wall invasion, lymph node involvement, and liver metastasis, supporting accurate staging.
7.Selective arterial angiography In cases not confirmed by routine examinations, angiography can demonstrate tumor vascular supply and assist diagnosis.
8.Endoscopic retrograde cholangiopancreatography (ERCP) The most effective approach for diagnosing ampullary-region carcinoma, with a high positivity rate and the ability to obtain pathological specimens concurrently.
9.Daily self-check for duodenal cancer Pay attention to symptoms such as abdominal pain, jaundice, and hematemesis, and undergo imaging follow-up as advised by clinicians.
Conclusion
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that early symptoms of duodenal cancer are subtle and can be misdiagnosed, and many patients are confirmed at intermediate to advanced stages. Early diagnosis and standardized treatment are key to improving survival. Patients should actively cooperate with treatment, select an appropriate surgical approach, and adhere to regular follow-up examinations.
Basis for Duodenal Cancer Diagnosis
1.Tumor mucin testing Assessment of mucin expression profiles can help clarify the tumor’s tissue of origin (including differentiation from periampullary cancers) and support individualized treatment planning.
2.Histopathological examination The diagnostic gold standard. Histology most commonly shows adenocarcinoma, with a minority of cases being mucinous adenocarcinoma or undifferentiated carcinoma.
3.Fecal occult blood testing A basic noninvasive screening method; results may be positive when tumor ulceration causes gastrointestinal bleeding.
4.Air–barium double-contrast study A preferred examination that can demonstrate mucosal irregularity, bowel wall rigidity, or filling defects.
5.Duodenal fiberoptic endoscopy Allows direct visualization of lesions and biopsy sampling; however, lesions in the third and fourth portions of the duodenum may be missed.
6.Ultrasonography, endoscopic ultrasonography, and CT Used to assess depth of bowel wall invasion, lymph node involvement, and liver metastasis, supporting accurate staging.
7.Selective arterial angiography In cases not confirmed by routine examinations, angiography can demonstrate tumor vascular supply and assist diagnosis.
8.Endoscopic retrograde cholangiopancreatography (ERCP) The most effective approach for diagnosing ampullary-region carcinoma, with a high positivity rate and the ability to obtain pathological specimens concurrently.
9.Daily self-check for duodenal cancer Pay attention to symptoms such as abdominal pain, jaundice, and hematemesis, and undergo imaging follow-up as advised by clinicians.
Conclusion
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that early symptoms of duodenal cancer are subtle and can be misdiagnosed, and many patients are confirmed at intermediate to advanced stages. Early diagnosis and standardized treatment are key to improving survival. Patients should actively cooperate with treatment, select an appropriate surgical approach, and adhere to regular follow-up examinations.