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Basis for Endometrial Cancer Diagnosis
1.Clinical presentation assessment
Attention is paid to symptoms such as abnormal vaginal bleeding and abnormal discharge, with preliminary evaluation based on history taking and gynecologic examination.
2.Ultrasonography
Transvaginal ultrasonography is the preferred screening modality, used to measure endometrial thickness and evaluate morphology and vascularity.
3.Hysteroscopy
Direct visualization of intrauterine lesions enables accurate localization and biopsy, providing high diagnostic accuracy.
4.Pathological biopsy
The diagnostic gold standard. Tissue is obtained for pathological analysis to determine histologic type and grade.
5.Imaging examinations
Pelvic MRI is used to assess depth of invasion, while CT/PET-CT evaluates metastatic disease to guide staging.
6.Tumor marker testing
Markers such as CA125 and HE4 assist diagnosis and treatment-response monitoring; combined testing improves sensitivity.
7.Molecular subtyping
Testing molecular biomarkers such as POLE and MSI guides individualized therapy and prognostic stratification.
8.Systemic evaluation
Comprehensive assessment is performed to evaluate overall condition and the presence of distant metastasis.
Conclusion
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes the importance of early diagnosis of endometrial cancer. Regular screening integrated with imaging and pathological examinations, together with stage- and molecular feature–based individualized treatment planning, can substantially improve cure rates and quality of life.
Basis for Endometrial Cancer Diagnosis
1.Clinical presentation assessment
Attention is paid to symptoms such as abnormal vaginal bleeding and abnormal discharge, with preliminary evaluation based on history taking and gynecologic examination.
2.Ultrasonography
Transvaginal ultrasonography is the preferred screening modality, used to measure endometrial thickness and evaluate morphology and vascularity.
3.Hysteroscopy
Direct visualization of intrauterine lesions enables accurate localization and biopsy, providing high diagnostic accuracy.
4.Pathological biopsy
The diagnostic gold standard. Tissue is obtained for pathological analysis to determine histologic type and grade.
5.Imaging examinations
Pelvic MRI is used to assess depth of invasion, while CT/PET-CT evaluates metastatic disease to guide staging.
6.Tumor marker testing
Markers such as CA125 and HE4 assist diagnosis and treatment-response monitoring; combined testing improves sensitivity.
7.Molecular subtyping
Testing molecular biomarkers such as POLE and MSI guides individualized therapy and prognostic stratification.
8.Systemic evaluation
Comprehensive assessment is performed to evaluate overall condition and the presence of distant metastasis.
Conclusion
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes the importance of early diagnosis of endometrial cancer. Regular screening integrated with imaging and pathological examinations, together with stage- and molecular feature–based individualized treatment planning, can substantially improve cure rates and quality of life.