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1. Abdominal pain
Persistent epigastric pain radiating to the back, worsened in the supine position and relieved by leaning forward, caused by tumor invasion of the nerve plexus.
2. Jaundice
Progressively worsening jaundice is characteristic of pancreatic head cancer, accompanied by dark urine, clay-colored stools, and pruritus.
3. Weight loss
Unexplained weight loss exceeding 10% within 6 months, closely associated with anorexia and tumor-related catabolism.
4. Gastrointestinal symptoms
Anorexia, nausea, abdominal distension, and steatorrhea, with bulky, foul-smelling, floating stools.
5. New-onset diabetes
Some patients present with new-onset type 2 diabetes, or previously controlled diabetes may suddenly worsen and become difficult to manage.
6. Back pain
Persistent back pain due to invasion of the retroperitoneal nerve plexus, often worse at night, suggesting advanced disease and limited resectability.
7. Thrombosis
A tendency toward migratory thrombophlebitis with limb swelling and pain, representing a characteristic paraneoplastic syndrome associated with pancreatic cancer.
8. Neuropsychiatric symptoms
Some patients develop depression and anxiety, potentially related to tumor-associated neurotransmitter changes, and these symptoms may be overlooked.
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that pancreatic cancer is among the most aggressive gastrointestinal malignancies. Because symptoms are often insidious, diagnosis commonly occurs at an advanced stage, posing a serious threat to health. High vigilance for persistent abdominal pain, progressive jaundice, and weight loss is essential, and prompt medical evaluation is recommended. Standardized care can prolong survival, but early diagnosis remains pivotal. The public should understand risk factors, maintain healthy lifestyle practices, and respond proactively.
1. Abdominal pain
Persistent epigastric pain radiating to the back, worsened in the supine position and relieved by leaning forward, caused by tumor invasion of the nerve plexus.
2. Jaundice
Progressively worsening jaundice is characteristic of pancreatic head cancer, accompanied by dark urine, clay-colored stools, and pruritus.
3. Weight loss
Unexplained weight loss exceeding 10% within 6 months, closely associated with anorexia and tumor-related catabolism.
4. Gastrointestinal symptoms
Anorexia, nausea, abdominal distension, and steatorrhea, with bulky, foul-smelling, floating stools.
5. New-onset diabetes
Some patients present with new-onset type 2 diabetes, or previously controlled diabetes may suddenly worsen and become difficult to manage.
6. Back pain
Persistent back pain due to invasion of the retroperitoneal nerve plexus, often worse at night, suggesting advanced disease and limited resectability.
7. Thrombosis
A tendency toward migratory thrombophlebitis with limb swelling and pain, representing a characteristic paraneoplastic syndrome associated with pancreatic cancer.
8. Neuropsychiatric symptoms
Some patients develop depression and anxiety, potentially related to tumor-associated neurotransmitter changes, and these symptoms may be overlooked.
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that pancreatic cancer is among the most aggressive gastrointestinal malignancies. Because symptoms are often insidious, diagnosis commonly occurs at an advanced stage, posing a serious threat to health. High vigilance for persistent abdominal pain, progressive jaundice, and weight loss is essential, and prompt medical evaluation is recommended. Standardized care can prolong survival, but early diagnosis remains pivotal. The public should understand risk factors, maintain healthy lifestyle practices, and respond proactively.