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1. Cushing syndrome
Excess cortisol may cause central obesity, moon face, buffalo hump, purple striae, and hypertension.
2. Virilization
Excess androgen production may lead to hirsutism, acne, deepening of the voice, and clitoral enlargement in women.
3. Estrogen excess
In men, this may present as gynecomastia, decreased libido, testicular atrophy, and infertility.
4. Hyperaldosteronism
Refractory hypertension and persistent hypokalemia may occur, often accompanied by muscle weakness and polyuria.
5. Abdominal discomfort
Tumor compression may cause distending pain in the lower back or flank, and an abdominal mass may sometimes be palpable.
6. Systemic symptoms
Weight loss, fatigue, decreased appetite, and fever may occur as the disease progresses.
7. Compression-related symptoms
Compression of the kidney, gastrointestinal tract, or nerves may cause pain or dysfunction in the affected area.
8. Symptoms from metastatic lesions
Liver metastasis may cause jaundice, lung metastasis may cause cough or hemoptysis, and bone metastasis may cause bone pain.
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that adrenal cancer is a rare but highly malignant endocrine tumor with complex and easily overlooked symptoms. It progresses rapidly and tends to metastasize early, posing a serious threat to life. Improving awareness of its characteristic manifestations is essential. High-risk individuals should remain vigilant and seek medical evaluation promptly. Early standardized treatment and multidisciplinary collaboration are key to improving prognosis.
1. Cushing syndrome
Excess cortisol may cause central obesity, moon face, buffalo hump, purple striae, and hypertension.
2. Virilization
Excess androgen production may lead to hirsutism, acne, deepening of the voice, and clitoral enlargement in women.
3. Estrogen excess
In men, this may present as gynecomastia, decreased libido, testicular atrophy, and infertility.
4. Hyperaldosteronism
Refractory hypertension and persistent hypokalemia may occur, often accompanied by muscle weakness and polyuria.
5. Abdominal discomfort
Tumor compression may cause distending pain in the lower back or flank, and an abdominal mass may sometimes be palpable.
6. Systemic symptoms
Weight loss, fatigue, decreased appetite, and fever may occur as the disease progresses.
7. Compression-related symptoms
Compression of the kidney, gastrointestinal tract, or nerves may cause pain or dysfunction in the affected area.
8. Symptoms from metastatic lesions
Liver metastasis may cause jaundice, lung metastasis may cause cough or hemoptysis, and bone metastasis may cause bone pain.
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that adrenal cancer is a rare but highly malignant endocrine tumor with complex and easily overlooked symptoms. It progresses rapidly and tends to metastasize early, posing a serious threat to life. Improving awareness of its characteristic manifestations is essential. High-risk individuals should remain vigilant and seek medical evaluation promptly. Early standardized treatment and multidisciplinary collaboration are key to improving prognosis.