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Buccal Mucosa Cancer Treatment Modalities
1.Surgical treatment
Radical resection of the tumor with negative safety margins is the cornerstone of curative treatment.
2.Neck lymph node dissection
Patients with intermediate to advanced disease and nodal metastasis undergo systematic neck dissection during the same treatment course.
3.Microsurgical reconstruction and repair
Free tissue flaps are used for immediate reconstruction of buccal defects to restore appearance and function.
4.Radiotherapy
Radiotherapy can be curative in early-stage disease and is used as adjuvant therapy in patients with high-risk factors after surgery; intensity-modulated radiotherapy provides precise and safe delivery.
5.Chemotherapy
Concurrent chemoradiotherapy or neoadjuvant induction chemotherapy, commonly using platinum-based and 5-fluorouracil–based regimens.
6.Targeted therapy
Cetuximab combined with radiotherapy may be used in locally advanced disease with high EGFR expression.
7.Immunotherapy
PD-1 inhibitors are used for recurrent/metastatic disease, with greater benefit observed in patients with high PD-L1 expression.
8.Multidisciplinary collaborative model
An MDT team makes joint decisions and develops an individualized treatment sequence.
9.Intraoperative frozen-section pathology
Real-time assessment of surgical margins to ensure complete tumor resection.
10.Precision therapy guided by molecular subtyping
Testing biomarkers such as EGFR and PD-L1 supports a stratified approach and enables individualized treatment strategies.
11.Supportive care and adverse event management
Comprehensive nutritional support, pain control, and management of chemoradiotherapy-related adverse events throughout the treatment course to ensure treatment completion.
Conclusion
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that early diagnosis of buccal mucosa cancer is a prerequisite for function-preserving cure. An MDT-based approach integrating radical surgery, precision radiotherapy, systemic therapies, and microsurgical reconstruction, with a commitment to individualized precision treatment, can maximize survival benefit while optimizing long-term quality of life.
Buccal Mucosa Cancer Treatment Modalities
1.Surgical treatment
Radical resection of the tumor with negative safety margins is the cornerstone of curative treatment.
2.Neck lymph node dissection
Patients with intermediate to advanced disease and nodal metastasis undergo systematic neck dissection during the same treatment course.
3.Microsurgical reconstruction and repair
Free tissue flaps are used for immediate reconstruction of buccal defects to restore appearance and function.
4.Radiotherapy
Radiotherapy can be curative in early-stage disease and is used as adjuvant therapy in patients with high-risk factors after surgery; intensity-modulated radiotherapy provides precise and safe delivery.
5.Chemotherapy
Concurrent chemoradiotherapy or neoadjuvant induction chemotherapy, commonly using platinum-based and 5-fluorouracil–based regimens.
6.Targeted therapy
Cetuximab combined with radiotherapy may be used in locally advanced disease with high EGFR expression.
7.Immunotherapy
PD-1 inhibitors are used for recurrent/metastatic disease, with greater benefit observed in patients with high PD-L1 expression.
8.Multidisciplinary collaborative model
An MDT team makes joint decisions and develops an individualized treatment sequence.
9.Intraoperative frozen-section pathology
Real-time assessment of surgical margins to ensure complete tumor resection.
10.Precision therapy guided by molecular subtyping
Testing biomarkers such as EGFR and PD-L1 supports a stratified approach and enables individualized treatment strategies.
11.Supportive care and adverse event management
Comprehensive nutritional support, pain control, and management of chemoradiotherapy-related adverse events throughout the treatment course to ensure treatment completion.
Conclusion
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that early diagnosis of buccal mucosa cancer is a prerequisite for function-preserving cure. An MDT-based approach integrating radical surgery, precision radiotherapy, systemic therapies, and microsurgical reconstruction, with a commitment to individualized precision treatment, can maximize survival benefit while optimizing long-term quality of life.