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1. Neoadjuvant chemotherapy
Preoperative chemotherapy reduces tumor burden, eradicates micrometastases, and facilitates limb-salvage surgery.
2. Limb-salvage surgery
Complete tumor resection with preservation of limb function; 3D-printed prostheses can be customized to match skeletal defects with high precision.
3. Minimally invasive treatment
Radiofrequency ablation, cryoablation, and other small-incision approaches can target selected small lesions while preserving uninvolved bone.
4. Adjuvant chemotherapy
Postoperative chemotherapy eliminates residual malignant cells and reduces the risk of recurrence and metastasis.
5. Radiotherapy
Used for unresectable sites, postoperative residual disease, or palliative pain control; advanced precision techniques may improve efficacy.
6. Targeted therapy
Agents directed at specific molecular targets may inhibit oncogenic signaling pathways in selected patients.
7. Immunotherapy
Strategies that activate antitumor immunity, including immune checkpoint inhibitors and CAR-T therapies.
8. 3D-printed prosthetic reconstruction
Patient-specific implants precisely match bone defects and may be particularly suitable for adolescents.
9. Combined cryo–thermal ablation
Freeze–thaw cycles destroy tumor tissue while maximizing preservation of the epiphysis, which may benefit pediatric patients.
10. Radiomics-guided treatment
Extraction of quantitative imaging features to predict treatment response, enabling individualized precision medicine.
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that osteosarcoma is highly malignant and predominantly affects adolescents, potentially causing severe pain, fractures, and metastasis. Early standardized diagnosis and treatment are essential. Multimodal management centered on surgery (neoadjuvant chemotherapy plus adjuvant chemotherapy) can significantly improve survival. Minimally invasive approaches and 3D-printing technologies provide additional limb-salvage options, and structured follow-up is critical for recurrence prevention.
1. Neoadjuvant chemotherapy
Preoperative chemotherapy reduces tumor burden, eradicates micrometastases, and facilitates limb-salvage surgery.
2. Limb-salvage surgery
Complete tumor resection with preservation of limb function; 3D-printed prostheses can be customized to match skeletal defects with high precision.
3. Minimally invasive treatment
Radiofrequency ablation, cryoablation, and other small-incision approaches can target selected small lesions while preserving uninvolved bone.
4. Adjuvant chemotherapy
Postoperative chemotherapy eliminates residual malignant cells and reduces the risk of recurrence and metastasis.
5. Radiotherapy
Used for unresectable sites, postoperative residual disease, or palliative pain control; advanced precision techniques may improve efficacy.
6. Targeted therapy
Agents directed at specific molecular targets may inhibit oncogenic signaling pathways in selected patients.
7. Immunotherapy
Strategies that activate antitumor immunity, including immune checkpoint inhibitors and CAR-T therapies.
8. 3D-printed prosthetic reconstruction
Patient-specific implants precisely match bone defects and may be particularly suitable for adolescents.
9. Combined cryo–thermal ablation
Freeze–thaw cycles destroy tumor tissue while maximizing preservation of the epiphysis, which may benefit pediatric patients.
10. Radiomics-guided treatment
Extraction of quantitative imaging features to predict treatment response, enabling individualized precision medicine.
Jinshazhou Hospital of Guangzhou University of Chinese Medicine emphasizes that osteosarcoma is highly malignant and predominantly affects adolescents, potentially causing severe pain, fractures, and metastasis. Early standardized diagnosis and treatment are essential. Multimodal management centered on surgery (neoadjuvant chemotherapy plus adjuvant chemotherapy) can significantly improve survival. Minimally invasive approaches and 3D-printing technologies provide additional limb-salvage options, and structured follow-up is critical for recurrence prevention.